Postoperative care begins in the recovery room and continues throughout the recovery period. Critical concerns are airway clearance, pain control, mental status, and wound healing. Other important concerns are preventing urinary retention, constipation, deep venous thrombosis, and BP variability (high or low). For patients with diabetes, plasma glucose levels are monitored closely by fingerstick testing every 1 to 4 h until patients are awake and eating because better glycemic control improves outcome. Airway: Most patients are extubated before leaving the operating room and soon become able to clear secretions from their airway. Patients should not leave the recovery room until they can clear and protect their airway (unless they are going to an ICU). After intubation, patients with normal lungs and trachea may have a mild cough for 24 h after extubation; for smokers and patients with a history of bronchitis, postextubation coughing lasts longer. Most patients who have been intubated, especially smokers and patients with a lung disorder, benefit from an incentive inspirometer. Postoperative dyspnea may be caused by pain secondary to chest or abdominal incisions (nonhypoxic dyspnea) or by hypoxemia (hypoxic dyspnea—see also Approach to the Critically Ill Patient: Oxygen Desaturation). Hypoxemia secondary to pulmonary dysfunction is usually accompanied by dyspnea, tachypnea, or both; however, oversedation may cause hypoxemia but blunt dyspnea, tachypnea, or both. Thus, sedated patients should be monitored with pulse oximetry or capnometry. Hypoxic dyspnea may result from atelectasis or, especially in patients with a history of heart failure or chronic kidney disease, fluid overload. Whether dyspnea is hypoxic or nonhypoxic must be determined by pulse oximetry and sometimes ABGs; chest x-ray can help differentiate fluid overload from atelectasis. Hypoxic dyspnea is treated with oxygen. Nonhypoxic dyspnea may be treated with anxiolytics or analgesics. Pain: Pain control may be necessary as soon as patients are conscious (see Pain: Treatment of Pain). Opioids are typically the first-line choice and can be given orally or parenterally. Often, oxycodoneSome Trade Names OXYCONTIN OXYIR Click for Drug Monograph /acetaminophenSome Trade Names GENAPAP TYLENOL VALORIN Click for Drug Monograph 1 or 2 tablets (each tablet can contain 2.5 to 10 mg oxycodoneSome Trade Names OXYCONTIN OXYIR Click for Drug Monograph and 325 to 650 mg acetaminophenSome Trade Names GENAPAP TYLENOL VALORIN Click for Drug Monograph ) po q 4 to 6 h or morphineSome Trade Names DURAMORPH MS CONTIN MSIR ROXANOL Click for Drug Monograph 2 to 4 mg IV q 3 h is given as a starting dose, which is subsequently adjusted as needed; individual needs and tolerances can vary several-fold. With less frequent dosing, breakthrough pain, which should be avoided, is possible. For more severe pain, IV patient-controlled, on-demand dosing is best (see Pain: Dosing and titration). If patients do not have a renal disorder or a history of GI bleeding, giving NSAIDs at regular intervals may reduce breakthrough pain, allowing the opioid dosage to be reduced. Mental status: All patients are briefly confused when they come out of anesthesia. The elderly, especially those with dementia, are at risk of postoperative delirium, which can delay discharge and increase risk of death. Risk of delirium is high when anticholinergics are used. These drugs are sometimes used before or during surgery to decrease upper airway secretions, but they should be avoided whenever possible. Opioids, given postoperatively, may also cause delirium, as can high doses of H2 blockers. The mental status of elderly patients should be assessed frequently during the postoperative period. If delirium occurs, oxygenation should be assessed, and all nonessential drugs should be stopped. Patients should be mobilized as they are able, and any electrolyte or fluid imbalances should be corrected. Wound care: The surgeon must individualize care of each wound, but the sterile dressing placed in the operating room is generally left intact for 24 h unless signs of infection (eg, increasing pain, erythema, drainage) develop. After 24 h, the site should be checked twice/day, if possible, for signs of infection. If they occur, wound exploration and drainage of abscesses, systemic antibiotics, or both may be required. Topical antibiotics are usually not helpful. A drain tube, if present, must be monitored for quantity and quality of the fluid collected. Sutures, skin staples, and other closures are usually left in place 7 days or longer depending on the site and the patient. Face and neck wounds may be superficially healed in 3 days; wounds on the lower extremities may take weeks to heal to a similar degree. Deep venous thrombosis (DVT) prophylaxis: Risk of DVT after surgery is small, but because consequences can be severe and risk is still higher than that in the general population, prophylaxis is often warranted. Surgery itself increases coagulability and often requires prolonged immobility, another risk factor for DVT (see Pulmonary Embolism and see Peripheral Venous Disorders). Prophylaxis for DVT usually begins in the operating room (see Table 5: Pulmonary Embolism: Risk of Deep Venous Thrombosis and Pulmonary Embolism in Surgical PatientsTables). Alternatively, heparinSome Trade Names HEPFLUSH-10 Click for Drug Monograph may be started shortly after surgery, when risk of bleeding has decreased. Patients should begin moving their limbs as soon as it is safe for them to do so. Fever: A common cause of fever is a high metabolic rate that occurs with the stress of an operation. Other causes include pneumonia, UTIs, and wound infections. Incentive spirometry and periodic coughing can help decrease risk of pneumonia. Other issues: Certain types of surgery require additional precautions. For example, hip surgery requires that patients be moved and positioned so that the hip does not dislocate. Any physician moving such patients for any reason, including auscultating the lungs, must know the positioning protocol to avoid doing harm; often, a nurse is the best instructor. Urinary retention and constipation are common after surgery. Causes include use of anticholinergics or opioids, immobility, and decreased oral intake. Patients must be monitored for urinary retention. Straight catheterization is typically necessary for patients who have a distended bladder and are uncomfortable or who have not urinated for 6 to 8 h after surgery; Credé's maneuver sometimes helps and may make catheterization unnecessary. Chronic retention is best treated by avoiding causative drugs and by having patients sit up as often as possible. BethanecholSome Trade Names DUVOID URECHOLINE Click for Drug Monograph 5 to 10 mg can be tried in patients unlikely to have any bladder obstruction and who have not had a laparotomy; doses can be repeated every hour up to a maximum of 50 mg/day. Sometimes an indwelling bladder catheter is needed, especially if patients have a history of retention or a large initial output after straight catheterization. Constipation is treated by avoiding causative drugs and, if patients have not had GI surgery, by giving stimulant laxatives (eg, bisacodylSome Trade Names DULCOLAX Click for Drug Monograph , sennaSome Trade Names EX-LAX SENOKOT Click for Drug Monograph , cascara). Stool softeners (eg, docusateSome Trade Names COLACE SURFAK Click for Drug Monograph ) do not alleviate postoperative constipation. Loss of muscle mass (sarcopenia) and strength occur in all patients who require prolonged bed rest. With complete bed rest, young adults lose about 1% of muscle mass/day, but the elderly lose up to 5%/day because growth hormone levels decrease with aging. Avoiding sarcopenia is essential to recovery. Thus, patients should sit up in bed, transfer to a chair, stand, and exercise as much as and as soon as is safe for their surgical and medical condition. Nutritional deficiencies may also contribute to sarcopenia. Thus, nutritional intake of patients on complete bed rest should be optimized. Tube feeding or, rarely, parenteral feeding may be necessary.