What can make people angry? The most common factors that make people angry are: Grief - losing a loved one. Sexual frustration Rudeness Tiredness Hunger Pain Withdrawal from drugs or some medications Some physical conditions, such as pre-menstrual syndrome Physical illness Mental illness Alcohol, some drugs, alcohol abuse, drug abuse Injustice Being teased or bullied Humiliation Embarrassment Deadlines Traffic jams Disappointment Sloppy service Failure Infidelity Being told you have a serious illness Anger can make you ill When we are angry the body releases stress hormones, such as adrenaline, noradrenaline and cortisol. The heart rate, blood pressure, body temperature and breathing rate increase. Regular episodes of anger can eventually make people ill. Oher harms.