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Metabolic Pathway in Human Body
How long does fasting last each day during Ramadan?
14-15 hours, depending on the time of year.

What happens during fasting?
Gluconeogenesis

What is the metabolism of the human body?
The human body converts food and drinks into energy.

What are different types of metabolic pathways?
1. Glycolysis
2. Gluconeogenesis
3. Glycogenesis
4. Glycogenolysis
5. Citric Acid Cycle (Kreb's Cycle or Tricarboxylic Acid Cycle)
6. Oxidative Phosphorylation (Electron Transport Chain)
7. Pentose Phosphate Pathway (PPP)
8. Urea Cycle
9. Fatty Acid Oxidation
10. Creatinine and Creatine Metabolism

Questions you need to discuss.

What is the name of the metabolic process?
What is it?
What type of metabolic pathway is it?
What is the precursor?
What is the end product or ingredient?

These questions are discussed in a medical college for the education of specific physicians.

1. Glycolysis
What are the end products of glycolysis?
1. Pyruvate (2 molecules)
2. Reduced nicotinamide adenine dinucleotide, NADH (2 molecules)
3. Adenosine triphosphate, ATP (net 2 molecules, as 4 were produced but 2 were used in the energy consumption part at the beginning of glycolysis)

What happens to the end products of glycolysis?
In aerobic conditions, the presence of oxygen allows the pyruvate generated by glycolysis to enter the citric acid (or Kreb’s cycle) to continue its breakdown into more energy.

2. Gluconeogenesis
What is gluconeogenesis?
Gluconeogenesis means the breaking down of glycogen and the generation of glucose inside the human body.

Gluconeogenesis and physiological ketogenesis: Is there a difference?
Yes.

What is the difference between gluconeogenesis, physiological ketosis, and ketoacidosis?
Glycogen is your body’s primary form of stored carbs, and it can be converted back into sugar as a source of energy, as needed. During fasting, glycogen is converted to glucose.
After many hours of fasting, glycogen stores in the liver have been depleted, and your body begins breaking down protein and fat stores for energy instead. This results in the production of ketone bodies, a type of compound produced when your body converts fat into fuel.

3. Glycogenesis
What is glycogenesis?
Glycogenesis is the formation of glycogen from glucose.

4. Glycogenolysis
What is glycogenolysis?
Glycogenolysis is the process of synthesizing glucose from non-carbohydrate sources.

5. Citric Acid Cycle (Kreb's Cycle or Tricarboxylic Acid Cycle)
What is another word or term for the citric acid cycle?
Kreb's cycle
Tricarboxylic acid cycle

Where does the citric acid cycle occur?
Mitochondria matrix of the cells

Why is it called the citric acid cycle?
The name refers to the citric acid molecule, which is involved in one of the reaction steps.

What are the end products of the citric acid cycle?
Four molecules of acetyl CoA are converted into two molecules of carbon dioxide.

6. Oxidative Phosphorylation (Electron Transport Chain)
What products are formed during the cycle that carries electrons and hydrogen ions to the electron transport chain? NADH and FADH

7. Pentose Phosphate Pathway (PPP)
What is another word or term for the pentose phosphate pathway (PPP)?
Hexose monophosphate shunt

What is it?
It is a metabolic pathway parallel to glycolysis. The pathway is important in red blood cells (erythrocytes).

What are the end products of the pentose phosphate pathway (PPP)?
1. NADPH. This is absent in glycolysis.
2. Production of the ribose 5-phosphate used in the synthesis of nucleotides and nucleic acids.
3. Production of the erythrose 4-phosphate used in the synthesis of aromatic amino acids.
The end product of the pentose phosphate pathway enters into glycolysis, so it is a shunt glycolysis.

8. Urea Cycle
What is the urea cycle in the human body?
Ammonia is produced as amino acids break down or by the gut bacteria in humans.
Th urea cycle removes the ammonia from the blood and makes urea, which is eventually excreted as urine.

9. Fatty Acid Oxidation
What is fatty acid oxidation?
It consists of sequential oxidation (loss of electrons).

What is the end product of fatty acid oxidation?
Acetyl-CoA, which can then be used for the citric acid cycle for further oxidation and ATP production.

10. Creatinine and Creatine Metabolism
If creatinine is high, does that indicate kidney disease?
No.

What are the points in favor of this?
National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894
U.S. Department of Health and Human Services National Institutes of Health

MedlinePlus

https://medlineplus.gov/lab-tests/creatinine-test/
Abnormal results do not always mean kidney disease. The following conditions can temporarily raise creatinine levels:
    Intense exercise
    A diet high in red meat
    Certain medicines. Some medicines have side effects that raise creatinine levels.
What are your thoughts relevant to this issue?

Georgia Public Health Laboratory
https://dph.georgia.gov/lab
Blood Chemistry Analysis
Creatinine
Normal: 0.5 – 1.5 mg/dl

FDA normal values
Creatinine
Normal 1– 2 mg/dl